New York: The Pandemic’s Lethal Twilight

While everyone’s excited for “hot vaxx summer,” a reminder: Americans are still dying of COVID. Not in the same numbers as during last winter’s horrific peak, but still at an agonizing clip, with more than 700 fatalities a day on average. In other words, tens of thousands of otherwise healthy people walking around today will die of it in the months ahead.

Sure, there are plenty of reasons to feel optimistic. We now have highly effective vaccines, and close to half the adult U.S. population has gotten at least one dose, conferring a high degree of protection from the virus. Given that a third or more of the country may have built up immunity through already getting infected, that means we’re in striking distance of herd immunity, which will gradually drive new infections to sufficient rarity that the pandemic will effectively be over nationally. “We have reason to believe we’ll be in a good place by July,” says Justin Lessler, an infectious-disease epidemiologist at Johns Hopkins.

But it’s not at all clear how we’ll get there. After an unexpectedly successful rollout of the Pfizer and Moderna vaccines, uptake is now slowing, with many locations now having more doses than people taking them. Meanwhile, new variants of concern are emerging and spreading. One of them, B.1.1.7, first appeared around the New Year and now constitutes the majority of new infections in the United States.

“We’re in a footrace between the vaccine and the variants,” says Columbia University disease modeler Jeffrey Shaman. How that race plays out will make the difference between a gradually weakening pandemic that yields relatively few additional fatalities and one that drives the death toll to another spike. The experience of Michigan, where cases spiked eightfold between February and April even as overall caseloads in the U.S. were broadly declining, could be played out again and again in pockets of vulnerability. Continue reading New York: The Pandemic’s Lethal Twilight

New York: Why the Second COVID Shot Makes You Miserable

When the actress Sarah Wynter got her first dose of the Pfizer COVID-19 vaccine, she didn’t experience any side effects apart from a little soreness in her arm. Dose two was a different story. About 12 hours after she received it, as she was about to go to bed, “it hit me like a freight train,” she says. “I just started feeling very achy, very tired and heavy.”

She woke up the next morning experiencing what felt like the worst hangover of her life. After some Tylenol and coffee, she felt almost better by late morning and was well enough to host a small birthday party for her 10-year-old twins. Then, at bedtime, it was round two, this time including violent chills. A night’s rest helped, but the following day she still felt under the weather.

Wynter’s experiences may not have been exactly typical, but they weren’t unusual, either: The second dose of Moderna and Pfizer vaccines really do pack a wallop. A study by the Centers for Disease Control and Prevention found that while 30 percent of recipients experienced fatigue and a quarter suffered headaches after the first dose, those figures climbed to 54 percent and 46 percent, respectively, after the second dose. The number experiencing chills or fever climbed from 9 percent to 30 percent.

These unpleasant effects are a result of the way the immune system works. Continue reading New York: Why the Second COVID Shot Makes You Miserable

New York: So You’ve Been Vaccinated. When Are You Safe?

If you’ve recently received a COVID-19 vaccination, congratulations — but you’re not out of the woods. Right after your first dose, you’re as vulnerable to infection as you were before, since it takes time for your immune system to learn how to find and kill the coronavirus. When that happens, recipients of the Pfizer, Moderna, and Johnson & Johnson vaccines will all enjoy nearly 100 percent protection against hospitalization and death. So when can you start to feel safe? Sooner than you might think.

Pfizer and Moderna, the only vaccines to have published their Phase 3 trial results in a peer-reviewed journal, are both based on mRNA technology, and as might be expected showed similar trajectories. During the first two weeks after the first dose, recipients were almost as likely as control subjects given a placebo to develop COVID-19. But after that, the vaccinated infection rate dropped quickly. Pfizer’s data is more detailed, and it’s striking. Before day 11, vaccination offers very little protection. After day 11, the protection is substantial. Given the overall similarity in efficacy, presumably Moderna is the same way. (Johnson & Johnson’s vaccine uses a different technology, and detailed results of their Phase 3 study haven’t been published yet, so it’s harder to say what’s going on there.)

Rachel Roper, a professor of microbiology at East Carolina University, says this timing isn’t surprising. The body makes millions of white blood cells that are randomly shaped to match all possible unknown things. “Most just lie dormant and die, but if one binds a virus or other pathogen, it will become activated, and then proliferate, and then differentiate to be an effector cell, making antibodies or becoming a killer cell.  This is why it takes a week or two to get over an illness.  It takes time for these very few specific cells to activate and proliferate to large enough numbers to control infection.”

Looking at the Pfizer graph, the protection level is nearly binary: none, and then all. Day 11 after the first shot seems to be the magic point beyond which you can consider yourself vaccinated. Continue reading New York: So You’ve Been Vaccinated. When Are You Safe?

New York: The Story of One Dose

UPDATE: On April 13, the FDA and CDC recommended that use of Johnson & Johnson’s COVID-19 vaccine be suspended after six women developed serious blood clots after receiving a dose, one of whom died. The CDC will “review these cases and assess their potential significance,” the agencies said in a joint statement. While the cases amounted to less than one per million vaccinations, they resembled similar blood-clot events suffered by recipients of the vaccine made by AstraZeneca, which uses a similar adenovirus vector.

As an object, it’s not much: an inch and a half of glass with a stopper and some liquid inside. But a thimbleful of the stuff has amazing power — the ability to liberate us from our yearlong collective trauma. The fact that it’s available, scarcely a year after the start of a pandemic, is both an industrial miracle and a freakish stroke of luck; a decade ago, technology did not exist that could bring vaccines so quickly to the public’s arms.

Pfizer and Moderna crossed the finish line first, neck and neck, in December. The third and most recently approved vaccine was from Johnson & Johnson. The J&J vaccine holds some crucial advantages: Only one dose is required rather than two, and while the other approved vaccines expire 30 days after thawing, Johnson & Johnson’s lasts three months, making it easier to distribute in countries that lack an advanced cold chain. The story of the vaccine’s path from development to mass distribution is a lesson in the power of the global capitalist system — the network of corporations and supply chains that, though it can suffocate and disempower us as individuals, can also summon forth immense material and intellectual resources and deploy them for the greater good.

From the start, J&J struggled to catch a break. The pharmaceutical giant played it safe during development and lost crucial time, failed to get FDA approval for parts of its U.S. production chain, missed several delivery targets, and wound up with a vaccine that underperformed its rivals in clinical trials. Then, another obstacle: Last week, the New York Timesrevealed that the new batch J&J had pledged would be delayed even further, after a mix-up at a subcontractor’s production facility ruined 15 million doses. The Biden administration has since directed J&J to take over every aspect of vaccine production at the plant.

The setback was significant, but not fatal. The facility where the mix-up occurred was part of a production process that relies on a precise orchestration of timing, engineering, and logistical expertise across multiple continents, which makes it vulnerable to bad luck and human error. But the system is also resilient: When the batch of J&J doses was compromised, alternative supply lines were available to compensate for the failure. Here is how that entire tempestuous journey unfolded — the breakthroughs, the setbacks, and the way the pieces came together to bring vaccines to millions of arms. Continue reading New York: The Story of One Dose

Why Were the Ukrainians Aboard MH370? UPDATED

Within a few months of the disappearance of MH370 I began investigating why a Russian and two Ukrainians were on the plane, as I’ve previously described here and here.

I quickly learned that the two men jointly owned a furniture company in Odessa, Ukraine called Nika Mebel. The company started a website around June, 2013, that retailed furniture it made in its own factory. Within a few months it added furniture imported from China and Malaysia. On the site the company described itself like this: “Continuous improvement of technological equipment and staff training helped us grow into a large furniture manufacturing company in Ukraine….  Over a 15-year period of time, we managed to make ourselves known on most of the territory of Ukraine, as well as beyond its borders.”

In an affadavit filed in 2017 as part of her effort to have her husband declared legally dead, Tatiana Chustrak stated that:

“In the court session it was established that the applicant’s husband was engaged in private business, namely, with his friend and business partner, Deineka Sergey Grigorievich, had a shop for furniture production.
March 02, 2014, a man, along with a partner, went on a business trip abroad. The purpose of the trip was to visit the international furniture exhibition in Kuala Lumpur, the capital of Malaysia, and on March 8, it was planned to fly to Beijing Airport, China, and then fly to Guangzhou, China, where an international furniture exhibition was also planned. According to this plan, the relevant tickets were purchased.”

I hired researchers in Ukraine and asked them to reach out to Dmitriy Kozlov, the manager of Nika Mebel. I figured that he’d have detailed knowledge of the trip, because according to Nika Mebel’s filings he was the only person authorized to operate the company apart from Chustrak and Deineka — in effect, for years after their disappearance, he was Nika Mebel.

My investigators reported back to me: Continue reading Why Were the Ukrainians Aboard MH370? UPDATED

New York: Why Do Boeing 777 Engines Keep Exploding?

The engines on elderly Boeing 777 airliners are blowing up with worrisome frequency.

In 2018, the No. 11 fan blade on the right engine of a United Airlines 777 broke as the plane approached its destination, Honolulu. Its pieces, traveling at high speed, caused a cascade of failures within the engine’s intricate machinery such that within less than a second, the engine’s cover had blown off, leaving the naked core wobbling as it spun. Flying debris caused two punctures in the fuselage but the plane was able to land safely under the power of its remaining engine.

Last December, a Japan Airlines 777 suffered a similar engine failure after the No. 16 fan blade of its No. 1 engine broke en route between Naha, Japan, and Tokyo. That flight, too, landed safely.

And then on Saturday, another United Airlines 777 suffered an uncontained engine failure as it climbed out of Denver en route to Honolulu. Witnesses on the ground reported hearing an explosion before debris rained down on the town of Broomfield, Colorado. The pilot declared mayday and returned to Denver without further incident.

In all three cases, the aircraft were among the oldest in the worldwide 777 fleet, having been delivered in the first two years after the model was introduced in 1995. While the Pratt & Whitney PW-4000 engines in each case were likely not original to each plane — engines are regularly removed from planes for routine maintenance, then installed on different aircraft — the engines are generally of similar vintage to the aircraft on which they fly. In the 2018 incident, the engine that failed had been built in 1996 and had accumulated 77,593 hours flight hours and 13,921 cycles (combined takeoffs and landings). The blade that failed in the 2020 incident had experienced 43,060 flight hours and 33,518 cycles.

Patterns in aircraft accidents can be a sign of trouble. While one-off failures might be attributable to a freak coincidence or just bad luck, patterns suggest that a previously unsuspected danger is lurking. Continue reading New York: Why Do Boeing 777 Engines Keep Exploding?

New York: Ancient 777 Strews Debris Over Colorado

The United Airlines 777 that suffered an uncontained engine failure this afternoon over Broomfield, Colorado, was the third oldest 777 in operation. The aircraft, tail number N772UA, first flew in 1994 and was delivered to United in September, 1995, three months after the 777 made its first commercial flight for the airline that June.

United Airlines Flight 328 took off from Denver International Airport at 1 p.m. bound for Honolulu and was climbing through 12,000 feet altitude when its right engine suffered an uncontained engine failure, with internal parts breaking through the external casing and sending pieces of it flying.

The pilot immediately made a mayday call and returned for a safe landing at 1:29 p.m. No injuries have been reported on the ground or among the 231 passengers or ten crew.

One Broomfield homeowner got a close call, however, when the ten-foot-wide circular section of engine cowling came within feet of crushing either the house or the pickup truck and RV parked next to it. Other large pieces landed on an athletic field in a nearby park.

UA328’s engines were Pratt & Whitney PW4000s, each 16 feet long, weighing 16,000 pounds, and capable of generating more than 90,000 foot-pounds of thrust. Turbofan engines rarely fail in flight, and even when they do, they are designed such that pieces of the engine will be contained within the surrounding cowling. But the stacks of fan blades that heat and compress air to generate thrust must handle extremely high energies, and if one comes apart due to accumulated mechanical stress it can shatter, spewing a shotgun-like blast of metal fragments that in turn can destroy neighboring blades in a cascading fashion.

Such uncontained engine failures can be extremely dangerous, as flying pieces can hit fuel tanks, shred control surfaces, sever hydraulic lines, pierce an aircraft’s pressure hull, or hit passengers or crew. In 2018, a passenger aboard a Southwest 737 was killed when one of the plane’s engines exploded and a piece of debris shattered her window; the resulting depressurization caused the top half of her body to be sucked out through the breach.

Investigators from the National Transportation Safety Board will collect as many pieces as possible from the ground as well as examine the portion of the engine that remained attached and study flight data recorders in order to determine what caused the catastrophic failure. It’s not currently known if the engine that failed was the original delivered with the plane to United in 1995, but if so its maintenance history will receive special scrutiny. Repeated stresses over time can cause microscopic fractures within metal that will eventually propagate and ultimately break if not detected in time.

Three years ago, an eerily similar event happened to a sister aircraft of the 777 involved in Saturday’s accident. An aircraft with the tail number N773UA, operating as United flight 1175, was also en route to Honolulu when it suffered an uncontained failure of its right engine that resulted in its cowling getting ripped off.

In that accident, the plane was 40 minutes from the end of its flight, and landed safely in Honolulu. The NTSB later determined that one of the fan blades had suffered a fatigue crack that had grown over time despite repeated inspections. Built in 1996, the engine had been installed on the plane in 2015 and had 77,593 hours in operation since new.

That plane was the fourth 777 off Boeing’s production line; N772UA was the fifth. Both aircraft were delivered to United on the same day: September 29, 1995.

This article originally ran on February 20, 2021 in New York magazine.

New York: Transportation Authority Finds Pilot at Fault in Crash That Killed Kobe Bryant

The National Transportation Safety Board today made its final determination in the January 26, 2020, helicopter crash that killed Kobe Bryant, his 13-year-old daughter, Gianna, and seven others, finding that the mostly likely cause was that the pilot, Ara Zobayan, became disorientated after flying into clouds, at which point he lost control and flew into a hillside.

A contributing factor, the board declared, was that Zobayan likely felt self-imposed pressure to successfully complete his mission, which was to deliver Bryant and members of his daughter’s basketball team to a tournament taking place in Calabasas, California.

The findings dinged Zobayan’s employer, Island Express Helicopters Inc., for “inadequate review and oversight of the safety management processes.” The conclusions provided on Tuesday were largely consistent with analysis previously published in New York magazine and elsewhere.

The fatal flight had taken off 40 minutes before from an airport in Orange County and traveled north under a low overcast before turning west in an attempt to cross over a mountain pass in order to reach Calabasas, 17 miles to the west. But the pass was shrouded in clouds. Island Express helicopters are only legally allowed to fly under visual flight rules, meaning that its pilots could orient themselves by seeing the ground below them.

At the public hearing held before the NTSB board voted to approve the findings, members noted that Zobayan had ignored his own pilot training. Once he found himself in whiteout conditions, he should have leveled the helicopter, kept flying straight ahead, and slowed down. Instead he maintained high speed and attempted to climb twice as fast as recommended.

He might nonetheless have succeeded in punching up through the thousand-foot-thick cloud layer if he had managed to keep the helicopter flying straight ahead. To do this, he would have had to maintain intent focus on the flight instrument panel in front of him, lest he succumb to “the leans,” an illusion caused by the vestibular sensation that one is in a turn when one is not. However, a few seconds after he entered the clouds, an air-traffic controller asked him to press a button that would signal the helicopter’s location on the controller’s radar screen. This required him to move and shift his attention in a way that “could adversely affect his ability to effectively interpret the instruments and maintain control of the helicopter,” according to NTSB investigator Dujuan Sevillian.

Seconds later, he radioed to the controller that he was climbing to 4,000 feet. But he was already in a steep dive that would cause him to impact the ground at 184 mph.

Far from being an unusual type of accident, crashes resulting from pilots flying into clouds and becoming disoriented are a persistent problem. On average, there have been one of these fatal crashes every six months for the past decade.

The board noted that the fatal crash didn’t mean that Zobayan was a bad pilot, noting that he was generally held in high regard by colleagues and clients. As lead investigator Bill English put it, “Good people can make a bad decision, and we really want to get to the bottom of why.”

This article first ran on February 9, 2021 in New York magazine.

Vanity Fair: Kobe Bryant’s Tragic Flight

8:45 A.M.

On a Gloomy Sunday Morning last winter, Ara Zobayan stood in the Atlantic Aviation terminal at John Wayne International Airport in Orange County, California, and contemplated his flight-planning app. The helicopter pilot’s software showed a blanket of clouds covering the city. Beneath the thousand-foot-thick layer lay patchy haze. The poor visibility meant that large swaths of the region were unflyable.

This was a problem. The charter company OC Helicopters had hired Zobayan’s employer, Island Express Helicopters, to fly Kobe Bryant and seven companions to Camarillo, an airport on the coast 80 miles to the northwest.

Completing the mission was important to Zobayan. Island Express was a small operation, with six helicopters and as many pilots, and it ran on thin margins, according to former Island Express pilot Kurt Deetz. Its business mostly consisted of shuttling passengers back and forth between Long Beach and Catalina Island, a tourist destination 20 miles off the coast. Custom charter flights for high-net-worth individuals were less frequent but far more lucrative.

Of all the company’s VIPs, Bryant was the I-est. According to Deetz, not only did Bryant fly Island Express regularly—for any crosstown trip that a normal person would just drive—but his patronage lent the company a luster. “Kobe was their pride and joy,” says Deetz. “It was like, ‘Look at us, we’ve made it.’ ” Keeping Bryant happy was job one. And as with any client, that meant getting him where he wanted to go. Continue reading Vanity Fair: Kobe Bryant’s Tragic Flight